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Brain Circuits in Schizophrenia and Smoking

NCT01369966 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 42

Last updated 2018-04-05

No results posted yet for this study

Summary

Background:

\- Smoking is associated with serious health risks. People who have mental illness are more likely to smoke. Researchers are studying the brain circuits linked with smoking and nicotine craving. This study will look at whether a specific brain circuit can explain the high rate of smoking in people with schizophrenia.

Objectives:

\- To study brain activity in smokers and nonsmokers with and without schizophrenia, as well as their family members.

Eligibility:

* Current smokers (at least 100 cigarettes in the past year) and nonsmokers between 18 and 62 years of age in one of the following groups:
* Have been diagnosed with schizophrenia.
* Family members of those with schizophrenia.
* Healthy adults with no history of severe mental illness or brain trauma.
* Family members of the healthy adults.

Design:

* People in the study will be screened with a physical exam, medical history, questionnaires, and blood tests.
* They will have up to three visits: the screening visit and two study visits (each given 1 year apart).
* At the first study visit, those taking part will be trained in the tests they will do during the magnetic resonance imaging (MRI) scan. Then they will have the MRI scan.
* After the first study visit, current smokers will receive phone calls from the study researchers every other month for 1 year. They will be asked about their smoking habits.
* At the second study visit, current smokers and some nonsmokers will have another MRI scan and the same tests as before.
* Current smokers will receive a final phone call 1 year after the second study visit. They will be asked to give information about their smoking habits.

Conditions

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    lead NIH

Principal Investigators

  • Elliot Stein, Ph.D. · National Institute on Drug Abuse (NIDA)

Eligibility

Min Age
18 Years
Max Age
62 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-05-16
Completion
2014-12-24

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01369966 on ClinicalTrials.gov