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Intensive Cognitive-Behavioral Therapy For Obsessive-Compulsive Disorder

NCT01368510 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 75

Last updated 2020-03-24

No results posted yet for this study

Summary

Even with the best available treatments for obsessive-compulsive disorder (OCD), most patients only partially recover and many patients do not respond at all. Such incomplete and inadequate response contributes to greater public health costs in terms of morbidity and patient care expenses. This study aims for a better understanding of abnormal brain chemistry in OCD and how it is affected by cognitive-behavioral therapy (CBT) in order to develop novel therapies and improve the success of existing therapies. The main hypothesis is that CBT will change levels of the excitatory neurotransmitter glutamate in OCD patients in a region of the brain involved in OCD known as the cingulate cortex.

Conditions

  • Obsessive-Compulsive Disorder (OCD)

Interventions

BEHAVIORAL

Intensive Cognitive Behavioral Therapy (CBT)

Nondrug psychotherapy administered daily 5 days/week for 4 weeks

BEHAVIORAL

Waitlist

Minimal contact waitlist weekly for 4 weeks

Sponsors & Collaborators

Principal Investigators

  • Joseph O'Neill, PhD · UCLA Child Psychiatry

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-07-31
Primary Completion
2015-06-30
Completion
2015-06-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01368510 on ClinicalTrials.gov