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Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life

NCT01367977 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 21

Last updated 2024-02-14

No results posted yet for this study

Summary

It is known that 33-50% of Classic and Hypermobile Ehlers-Danlos Syndrome patients eventually develop dysautonomia, otherwise known as "POTS" (Postural Orthostatic Tachycardia Syndrome). Some of these patients develop dysautonomia as a result of a retroflexed odontoid, Chiari 1 Malformation or cranial settling and the resulting basilar impression. Many Ehlers-Danlos patients suffer with the same symptomology with no evidence of a cause according to MRI imaging.

It is the author's hypothesis that low-level External Communicating Hydrocephalus appears to be responsible for the constellation of autonomic and cranial nerve symptoms, and if present in the very young, an analysis of head circumference growth in the first 15 months of life should reflect abnormally rapid head growth, supporting this hypothesis.

Conditions

  • Ehlers Danlos Syndrome
  • External Hydrocephalus
  • Dysautonomia
  • Postural Orthostatic Tachycardia Syndrome
  • Venous Insufficiency

Sponsors & Collaborators

  • Genetic Disease Investigators

    lead OTHER

Principal Investigators

  • Diana L Driscoll, O.D. · Genetic Disease Investigators

Eligibility

Min Age
5 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-05-31
Primary Completion
2015-04-30
Completion
2015-04-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01367977 on ClinicalTrials.gov