Impact of Fish Oil Supplementation in 3rd Trimester of Pregnancy on Maternal and Offspring Health

Summary

The aim of the trial is to investigate the effect of daily supplementation with 2.7 grams of long chain n-3 fatty acids during the third trimester of pregnancy. In 1990, 533 pregnant women, while they were in gestational week 30, were randomized to fish oil supplements providing the mentioned amount of long chain n-3 fatty acids, olive oil supplements, or no supplements; they were asked to take the supplements until delivery. Health outcomes were assessed during pregnancy and delivery. Further, offspring health and development has been examined during the ensuring two decades by making linkages to the rich Danish health and administrative registries, by asking the offspring to complete web-based questionnaires, and by examining the offspring physically.

Conditions

• Preterm Delivery
• Atopy
• Metabolic Syndrome

Interventions

DIETARY_SUPPLEMENT

Fish oil

4 1-g gelatine capsules per day providing 2,7 grams long chain n-3 fatty acids

DIETARY_SUPPLEMENT

Olive oil

4 1-g gelatine capsules with virgin olive oil

Sponsors & Collaborators

• National Institutes of Health (NIH)

  collaborator NIH

• The Danish Council for Strategic Research

  collaborator OTHER

• Danish Council for Independent Research

  collaborator OTHER

• Lundbech Foundation

  collaborator UNKNOWN

• EU Commision, DG12

  collaborator UNKNOWN

• Centre for Fetal Programming, Denmark

  lead OTHER

Principal Investigators

• Sjurdur F. Olsen, MD · Statens Serum Institut

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

20 Years

Max Age

50 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

1989-11-30

Primary Completion

1990-12-31

Completion

2011-05-31

Countries

• Denmark

Study Locations