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Effect of Vitamin D Replacement in Patients With Urolithiasis

NCT01349764 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2016-05-05

No results posted yet for this study

Summary

When Vitamin D replacement is initiated in patients with history of urolithiasis, there will be higher incidence of hypercalciuria but with careful follow-up of these patients, hypercalciuria could be appropriately managed with thiazide diuretics so that the risk of newly diagnosed renal stones will be equivalent to control groups without Vitamin D replacements.the purpose of the study is to determine the effect of vitamin D replacement in patients with previous history of urolithiasis presenting to a tertiary stone clinic in terms of changes in 24-hour urine collection parameters and to evaluate the lithogenic effect of vitamin D replacement in terms of development of urolithiasis. Eighty-six eligible patients will be included in terms of having suboptimal vitamin D with history of calcareous urolithiasis and urinary calcium excretion \<7.5 mmol/day. Patients will be randomly divided into 2 equal groups depending on whether they will receive vitamin D replacement with follow-up at 3, 6, 12, \& 24 months.

Conditions

  • Urolithiasis

Interventions

DRUG

Vitamin D3

Sponsors & Collaborators

  • McGill University Health Centre/Research Institute of the McGill University Health Centre

    lead OTHER

Principal Investigators

  • Sero Andonian, MD, FRCS (C) · MUHC, Montreal QC, Canada

  • Ahsan Alam, MD, FRCP (C) · MUHC, Montreal QC, Canada

  • Ramsey Sabbagh, MD, FRCP (C) · MUHC, Montreal QC, Canada

  • Bernard Unikowsky, MD, FRCP (C) · MUHC, Montreal QC, Canada

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-04-30
Primary Completion
2016-05-31
Completion
2016-05-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01349764 on ClinicalTrials.gov