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Effects of Nucleus Basalis of Meynert Stimulation on Cognitive Disorders in Dementia With Lewy Bodies

NCT01340001 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 6

Last updated 2018-04-30

No results posted yet for this study

Summary

Deep brain stimulation has been developed as a substitute for the classical lesioning methods previously used in stereotactic and functional neurosurgery. Recent, anecdotal cases reports suggested that electrical stimulation of the cholinergic output of the Nucleus Basalis of Meynert (NBM) may improve cognitive performances, especially the memory tasks.

The present study aims to assess the effect of bilateral electrical stimulation of the NBM on the mnesic performance \[assessed by the sum of the three free recalls of the Free and Cued Selective Recall Reminding Test (FCSRT)\] in patients diagnosed with probable, moderate, Dementia with Lewy Bodies.

Conditions

  • Dementia With Lewy Bodies

Interventions

PROCEDURE

Electrical stimulation of the nucleus basalis of Meynert

Differents parameters will be assessed.

Sponsors & Collaborators

  • University Hospital, Rouen

    lead OTHER

Principal Investigators

  • Olivier GODEFROY, Md, PhD · University Hospital of Amiens

  • Luc DEFEBVRE, MD, PhD · University Hospital of Lille

  • HOUETO Jean-Luc, MD, PhD · University Hospital of Poitiers

  • Pierre Krystkowiak, MD, PhD · University Hospital of Amiens

  • Vincent Delasayette, MD · University Hospital of Caen

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-10-24
Primary Completion
2017-12-22
Completion
2017-12-22

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01340001 on ClinicalTrials.gov