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The Response of Intraocular Pressure to Systemic Hypercapnia and Hyperoxia

NCT01325285 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 14

Last updated 2011-08-18

No results posted yet for this study

Summary

The purpose of this study is to determine how intraocular pressure responds to changes in the levels of carbon dioxide or oxygen that a healthy individual inspires.

Conditions

  • Intraocular Pressure

Interventions

DEVICE

RespirAct

Participants will breathe through a mask connected to a sequential rebreathing circuit and gas blender. The following seven gas stages will be targeted for about 10 minutes each: 1. Baseline, measured in eye A (PETCO2=38mmHg and PETO2=100mmHg) 2. 10% hypercapnic increase, measured in eye A (PETCO2=42mmHg and PETO2=100mmHg) 3. 20% hypercapnic increase, measured in eye A (PETCO2=46mmHg and PETO2=100mmHg) 4. Baseline, measured in both eyes (PETCO2=38mmHg and PETO2=100mmHg) 5. 250% hyperoxic increase, measured in eye B (PETCO2=38mmHg and PETO2=250mmHg) 6. 500% hyperoxic increase, measured in eye B (PETCO2=38mmHg and PETO2=500mmHg) 7. Baseline, measured in eye B (PETCO2=38mmHg and PETO2=100mmHg)

Sponsors & Collaborators

  • University Health Network, Toronto

    collaborator OTHER

  • Thornhill Research

    collaborator UNKNOWN

  • University of Toronto

    lead OTHER

Principal Investigators

  • Christopher Hudson, PhD · University of Toronto

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-08-31
Primary Completion
2011-09-30
Completion
2011-09-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01325285 on ClinicalTrials.gov