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Oral Contraceptive (OC) Estrogen Dose and Breast Proliferation

NCT01318005 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 82

Last updated 2026-02-17

Study results available
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Summary

The purpose of this research study is to gain a better understanding of the changes that may occur in the breast when a woman uses an oral contraceptive (birth control pill). Some research indicates that women who use birth control pills with lower amounts of estrogen (a hormone in the birth control pill) may have lower breast cell growth than women who use birth control pills with a higher amount of estrogen; this research will examine that in detail.

Conditions

  • Oral Contraceptive

Interventions

DRUG

Oral Contraceptive: Ortho-Novum® 1/35

Oral Contraceptive: Ortho-Novum® 1/35, pill, 2-3 mos, daily.

DRUG

Oral Contraceptive: Ovcon® 35

Oral Contraceptive: Ovcon® 35, pill, 2-3 mos, daily.

DRUG

Oral Contraceptive: Microgestin Fe® 1/20

Oral Contraceptive: Microgestin Fe® 1/20, pill, 2-3 mos, daily.

Sponsors & Collaborators

  • University of Southern California

    lead OTHER

Principal Investigators

  • Heather MacDonald, M.D. · University of Southern California

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-02-14
Primary Completion
2014-06-30
Completion
2015-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01318005 on ClinicalTrials.gov