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Magnetic Resonance Technique in the Assessment of Exercise-induced Long- and Short-Term Changes in Cardiac Function and Morphology

NCT01305304 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2013-05-15

No results posted yet for this study

Summary

Until now it has been assumed that regular endurance training has a positive influence on cardiac function and that the positive effect increases with increasing intensity. However, little is known about the effects of intense endurance stress on the heart. According to current knowledge repeated exposure to strenuous endurance activity may lead to minor but possibly irreversible damage to the heart with resultant scarring of the heart's muscle.

Within this study the investigators attempt to find out by different analytical methods - in particular magnetic resonance imaging (MRI) and ultrasound of the heart - to what extent the heart muscle is affected by long term intense endurance exercise and which changes in cardiac function and morphology can possibly be found. Therefore the investigators compare former national competitive endurance athletes with sedentary controls.

Conditions

  • Myocardial Ischemia
  • Myocardial Infarction
  • Ventricular Remodeling
  • Myocardial Contraction
  • Ventricular Hypertrophy

Interventions

OTHER

repeated long term endurance exercise

competitive running at a national level during a period of at least 5 years (i.e. approximately 50km per week over more than 10 years)

OTHER

Other

No history of endurance sports activity

Sponsors & Collaborators

  • Federal Office of Sports, Switzerland

    collaborator OTHER_GOV

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Michael Ith, PhD, PhD/MD · Dept. of Diagnostic, Interventional and Pediatric Radiology, University Hospital Bern

  • Christoph Stettler, MD · Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Bern

Eligibility

Min Age
40 Years
Max Age
65 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-01-31
Primary Completion
2012-05-31
Completion
2012-07-31

Countries

  • Switzerland

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01305304 on ClinicalTrials.gov