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Bronchial Hyperreactivity in Children With Crohn Disease

NCT01297907 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 47

Last updated 2011-02-17

No results posted yet for this study

Summary

Background: Latent pulmonary involvement is described in Crohn Disease(CD). Bronchial hyperreactivity measured by the Methacholine Challenge Test (MCT) has been evaluated in two studies involving mainly adults.Our aim was to determine the frequency of bronchial hyperreactivity in pediatric patients followed and treated for Crohn disease.

Methods: Twenty-three children with Crohn disease completed a questionnaire, followed by spirometry, Methacholine Challenge Test (MCT) and determination of Fractional Exhaled NO (FENO). The control group included patients evaluated for functional cough who had negative Methacholine Challenge Test (MCT).

Conditions

Interventions

OTHER

Methacholine Challenge Test

Methacholine challenge test to evaluate airway hyperreactivity

OTHER

Fractional Exhaled NO (FENO)

Fractional Exhaled NO to evaluate eosinophilic inflammation

OTHER

Blood Test

Blood Tests (Eosinophil Count)

OTHER

PCDAI

Clinical Evaluation for Pediatric Crohn's Disease Activity Index (PCDAI)

Sponsors & Collaborators

  • Rambam Health Care Campus

    lead OTHER

Eligibility

Min Age
6 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-05-31
Primary Completion
2009-12-31
Completion
2009-12-31

Countries

  • Israel

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01297907 on ClinicalTrials.gov