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Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men

NCT01294319 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 51

Last updated 2024-07-15

Study results available
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Summary

This study proposes to examine multiple aspects of the hypothalamic-pituitary-adrenal axis in younger endurance trained and sedentary men, and in older sedentary men.

Conditions

  • Cortisol Resistance
  • Negative Feedback
  • ACTH
  • Mineralcorticoid
  • Glucocorticoid

Interventions

DRUG

Mifepristone

DRUG

Placebo

DRUG

Spironolactone

DRUG

Combined

DRUG

Dexamethasone

Sponsors & Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    lead NIH

Principal Investigators

  • Lynnette K Nieman, M.D. · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-01-24
Primary Completion
2016-08-10
Completion
2016-08-10
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01294319 on ClinicalTrials.gov