Effect of Body-mass Index (BMI) on Median Effective Dose of Intrathecal Hyperbaric Bupivacaine

Summary

The effect of Body-mass index (BMI) on requirements of local anesthetics used in spinal anesthesia has not been well established. The investigators tried to quantify the effect of BMI on spinal anesthesia by comparing the median effective dose of intrathecal bupivacaine between two different BMI groups.

Conditions

• Arthroplasty, Knee

Interventions

DRUG

BPV6NO

intrathecal bupivacaine 6 mg for BMI less than 27.5 kg/m2

DRUG

BPV7NO

intrathecal bupivacaine 7 mg for BMI less than 27.5 kg/m2

DRUG

BPV8NO

intrathecal bupivacaine 8 mg for BMI less than 27.5 kg/m2

DRUG

BPV9NO

intrathecal bupivacaine 9 mg for BMI less than 27.5 kg/m2

DRUG

BPV10NO

intrathecal bupivacaine 10 mg for BMI less than 27.5 kg/m2

DRUG

BPV11NO

intrathecal bupivacaine 11 mg for BMI less than 27.5 kg/m2

DRUG

BPV6O

intrathecal bupivacaine 6 mg for BMI over 27.5 kg/m2

DRUG

BPV7O

intrathecal bupivacaine 7 mg for BMI over 27.5 kg/m2

DRUG

BPV8O

intrathecal bupivacaine 8 mg for BMI over 27.5 kg/m2

DRUG

BPV9O

intrathecal bupivacaine 9 mg for BMI over 27.5 kg/m2

DRUG

BPV10O

intrathecal bupivacaine 10 mg for BMI over 27.5 kg/m2

DRUG

BPV11O

intrathecal bupivacaine 11 mg for BMI over 27.5 kg/m2

Sponsors & Collaborators

• Seoul Medical Center

  lead OTHER

Principal Investigators

• Won Ho Kim, M.D. · Seoul Medical Center

Study Design

Allocation

RANDOMIZED

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

40 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-01-31

Primary Completion

2010-12-31

Completion

2010-12-31

Countries

• South Korea

Study Locations