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Comparison of Goal-directed Algorithms of Hemodynamic Therapy After Combined Valve Repair

NCT01276444 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 43

Last updated 2011-01-13

No results posted yet for this study

Summary

Valvular repair and repair surgery is rapidly progressing yet rather challenging aspect of current cardiosurgical practice.

Several approaches were introduced into the clinical practice to alleviate systemic inflammatory response induced by cardiopulmonary bypass and organ-specific injury including meticulous haemodynamic monitoring, pharmacological heart preconditioning, systemic use of anti-inflammatory agents, prevention of coagulopathy, and induced topical and systemic hypothermia. An in-depth monitoring of haemodynamics, oxygen transport, and vascular permeability is of a great clinical value to control the efficacy of these approaches.

Therefore, the aim of this study was to compare two algorithms of goal-directed therapy aimed to achieve a postoperative haemodynamic optimization in combined valve repair surgery.

Conditions

  • Valvular Heart Disease

Interventions

DEVICE

Swan-Ganz catheter

the data s=derived from PAC included pulmonary artery occlusion pressure etc

DEVICE

transpulmonary thermodilution + central venous saturation

Described in details above

Sponsors & Collaborators

  • University of Tromso

    collaborator OTHER

  • Northern State Medical University

    lead OTHER

Principal Investigators

  • Mikhail Y. Kirov, MD, PhD · Northern State Medical University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-01-31
Primary Completion
2010-08-31
Completion
2010-09-30

Countries

  • Russia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01276444 on ClinicalTrials.gov