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Aging and Estrogen on Cortical Function

NCT01268046 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 38

Last updated 2018-08-22

Study results available
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Summary

This study will focus on how estrogen affects parts of the brain associated with memory and how the effect of estrogen is altered with aging in postmenopausal women.

Conditions

  • Memory Loss
  • Cognitive Changes
  • Postmenopausal Symptoms

Interventions

DRUG

Estradiol oral capsule

1 oral capsule (1 mg estradiol) administered daily for one month

DRUG

transderman estrogen patch

transdermal estrogen patch (50 mcg/day) for one month

DRUG

trasdermal placebo patch

transdermal placebo patch with patch change every 84 hr for one month

DRUG

placebo oral capsule

placebo oral capsule administered daily for one month.

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Janet E Hall, MD · Massachusetts General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
45 Years
Max Age
80 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-11-30
Primary Completion
2013-12-02
Completion
2013-12-02
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01268046 on ClinicalTrials.gov