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Transfusion Strategies in Weaning Patients

NCT01256645 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2010-12-08

No results posted yet for this study

Summary

The aim of this study is to determine, whether a liberal transfusion strategy is helpful to liberate patients from prolonged invasive mechanical ventilation.

Patients who are difficult to wean according to the criteria by Boles et al \[1\] are limited by the capacity of their respiratory muscles.

Improved oxygen delivery achieved by blood transfusions however is known to decrease the work of breathing \[2\] and thus in theory can improve weaning success \[3\].

This study is designed as a prospective, randomized, open labeled blinded End-point evaluation to test the hypothesis that a liberal transfusion strategy decreases the time needed for weaning.

1. Boles, JM, J Bion, A Connors, M Herridge, B Marsh, C Melot, R Pearl, H Silverman, M Stanchina, A Vieillard-BaronandT Welte, Weaning from mechanical ventilation. Eur Respir J, 2007. 29(5): p. 1033.
2. Schonhofer, B, M Wenzel, M GeibelandD Kohler, Blood transfusion and lung function in chronically anemic patients with severe chronic obstructive pulmonary disease. Crit Care Med, 1998. 26(11): p. 1824.
3. Schonhofer, B, H BohrerandD Kohler, Blood transfusion facilitating difficult weaning from the ventilator. Anaesthesia, 1998. 53(2): p. 181.

Conditions

  • Weaning Patients

Interventions

OTHER

blood transfusion

application of single units of red blood cell transfusions

Sponsors & Collaborators

  • Krankenhaus Kloster Grafschaft

    lead OTHER

Principal Investigators

  • Dieter Köhler, Prof · FKKG

  • Dominic Dellweg, M.D. · FKKG

  • Thomas Barchfeld, M.D. · FKKG

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-12-31
Primary Completion
2013-02-28
Completion
2013-02-28

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01256645 on ClinicalTrials.gov