MedTrace Logo

Cocaine/Crack and Reduction of Compulsion With Biperiden

NCT01251393 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 111

Last updated 2020-10-14

Study results available
· View outcomes & findings →

Summary

Considering the effects of the cholinergic system on the drug reward and self-administration mechanisms, acetylcholine (Ach) may play an important role on cocaine dependence process. Then the present study aims to evaluate biperiden efficacy (a cholinergic antagonist) in attenuate compulsion, one o the main symptoms of the drug dependence.

Conditions

  • Cocaine Dependence

Interventions

DRUG

Biperiden

Thirty volunteers will take three pills of Biperiden (6mg/day) during two months.

DRUG

Placebo

Thirty volunteers will take three pills of Placebo (6mg/day) during two months.

Sponsors & Collaborators

  • Nacional Conseling of Scientific Development and Technology

    collaborator OTHER

  • Federal University of São Paulo

    lead OTHER

Principal Investigators

  • José C F. Galduróz · Universidade Federal de São Paulo

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-05-31
Primary Completion
2011-12-31
Completion
2012-11-30

Countries

  • Brazil

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01251393 on ClinicalTrials.gov