Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases

Summary

RATIONALE: Bafetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

PURPOSE: This clinical trial studies bafetinib in treating patients with recurrent high-grade glioma or brain metastases.

Conditions

• Adult Anaplastic Astrocytoma
• Adult Anaplastic Ependymoma
• Adult Anaplastic Oligodendroglioma
• Adult Giant Cell Glioblastoma
• Adult Glioblastoma
• Adult Gliosarcoma
• Adult Mixed Glioma
• Recurrent Adult Brain Tumor
• Tumors Metastatic to Brain
• Adult Anaplastic Oligoastrocytoma

Interventions

DRUG

bafetinib

Given orally

PROCEDURE

microdialysis

Catheter placed intracerebrally during debulking craniotomy or stereotactic biopsy

OTHER

pharmacological study

Correlative studies

OTHER

liquid chromatography

Correlative studies

OTHER

mass spectrometry

Correlative studies

OTHER

laboratory biomarker analysis

Correlative studies

GENETIC

protein expression analysis

Correlative studies

GENETIC

western blotting

Correlative studies

OTHER

immunohistochemistry staining method

Correlative studies

PROCEDURE

therapeutic conventional surgery

debulking craniotomy

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• City of Hope Medical Center

  lead OTHER

Principal Investigators

• Jana Portnow · City of Hope Medical Center

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-12-31

Primary Completion

2013-03-31

Completion

2013-03-31

Countries

• United States

Study Locations