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Functional Magnetic Resonance Imaging (fMRI) Findings in Children With Early Exposure to General Anesthesia

NCT01229514 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2012-08-02

No results posted yet for this study

Summary

General anesthetic medications have been shown to cause neuronal cell death in the brains of infant rodents. Ethanol and general anesthetics both act on NMDA and GABA receptors,and appear to have similar mechanisms of toxicity in the immature rodent brain. Functional MRI (fMRI) is a technique developed for mapping brain activation and has been utilized to examine how the brains of children with a history of early exposure to ethanol function differently from children without such a history. This study will utilize fMRI to look for specific changes in brain activation patterns in children with a history of early exposure to general anesthesia, as compared to children without such exposure.

Conditions

  • Exposed to Anesthesia

Interventions

OTHER

fMRI

fMRI and a response inhibition task to examine activation patterns in the prefrontal cortex and caudate nucleus

Sponsors & Collaborators

  • Nationwide Children's Hospital

    lead OTHER

Principal Investigators

  • Thomas Taghon, DO · Nationwide Children's Hospital

Eligibility

Min Age
10 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-10-31
Primary Completion
2011-06-30
Completion
2011-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01229514 on ClinicalTrials.gov