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Optimizing Insulin Absorption and Insulin Injection Technique in Older Adults

NCT01213901 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2018-01-18

No results posted yet for this study

Summary

To determine which anatomic site offers the most consistent (superior) absorption of insulin.

To determine the injection technique which allows the most consistent subcutaneous injection of insulin (to pinch or to spread).

Hypothesis:

Based on age-related changes in the amount of subcutaneous fat we anticipate that the absorption of insulin from various anatomical sites will differ.

Justification:

To date health care professionals have extrapolated data obtained from younger adults and applied the results to the elderly.

Objectives:

To determine the rate of insulin absorption from different anatomic sites in diabetic patients over the age of 70.

To determine the best practice for subcutaneous injection in older adults.

Research Method:

Measurement of serial glucose and insulin levels using 360 minute euglycemic clamp studies.

Statistical Analysis:

Paired t test, repeated measures ANOVA

Conditions

Interventions

PROCEDURE

Lispro insulin

Each patient will receive 2 insulin injections in the abdomen: Once using a pinch method and once using a spread method.

Sponsors & Collaborators

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Gale Tedder · Vancouver Coastal Health Research Institute

  • Chris Lockhart · Vancouver Coastal Health Research Institute

  • Lee Ann Trimble · Vancouver Coastal Health Research Institute

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-09-30
Primary Completion
2012-07-31
Completion
2014-03-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01213901 on ClinicalTrials.gov