Karolinska Cardiorenal Theme-centre and StockholmHeartbank

Summary

Chronic kidney disease (CKD) affects 10-18% of the adult population and is becoming recognized as one of the most serious disorders causing increased risk for cardiovascular disease and death. In patients with ischemic heart disease 26% have increased creatinine, which rises to 40% if patients also have diabetes mellitus. Risk increases as renal function diminishes, and just slowing the rate of decline in renal function would have a tremendous impact on health and morbidity. This association is commonly termed the Cardiorenal Syndrome, though it is caused by a much more complex interplay between major pathogenetic pathways such as glucose metabolism and diabetes, systemic and tissue inflammation, tissue metabolism, coagulation, mineral metabolism, sympathetic activation, renin-angiotensin-aldosterone system activation, endothelial dysfunction, lipid metabolism, fetal programming etc.

Karolinska Institutet recently merged basic and clinical researchers in all these fields, creating a Karolinska Kardiorenal Theme Centre; ultimately aiming to explore the syndrome and provide improved care for the individual patient.

The investigators road to success:

* Creating a Biobank (blood, DNA, plasma) from the majority of all hosptalized patients with ACS in Stockholm county - Stockholmheartbank.
* This Theme Center include all teaching hospitals associated with Karolinska Institutet; Danderyd University Hospital, Karolinska University Hospital and Södersjukhuset University Hospital. Together theses hospitals serve as emergency hospitals for 1.9 million people. The investigators are aiming at creating a biobank from all patients admitted for an acute coronary event (about 2.300/yr), which is a unique asset for molecular and genetic research as well as observational and intervention studies.
* The investigators have access to the National registry with 100% coverage, that contains data on all patients admitted to Stockholms coronary care units since 1995.
* To ensure translation in to clinical practice, most of the researchers are also MD:s, and several are clinically active.
* The clinical network facilitates the development of novel therapies and translational research.
* Steering groups for Education and a Clinical Practice implementation program.

Conditions

• Chronic Kidney Disease
• Chronic Renal Failure
• Acute Coronary Syndrome
• Ischemic Heart Disease
• Myocardial Infarction

Sponsors & Collaborators

• Region Stockholm

  collaborator OTHER_GOV

• Karolinska Institutet

  collaborator OTHER

• Uppsala University

  collaborator OTHER

• Lund University

  collaborator OTHER

• Stockholm South General Hospital

  collaborator OTHER

• Karolinska University Hospital

  collaborator OTHER

• Danderyd Hospital

  lead OTHER

Principal Investigators

• Jonas Spaak, MD PhD · Karolinska Institutet and Danderyd University Hospital

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-05-31

Primary Completion

2022-05-31

Completion

2024-01-31

Countries

• Sweden

Study Locations