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Aqueous Humor Dynamics and Brimonidine

NCT01144494 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 35

Last updated 2023-11-28

Study results available
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Summary

This single-center, investigator-masked, crossover study is designed to investigate the circadian rhythms of aqueous humor dynamics in human subjects with ocular hypertension (OHT) before and after intervention with a commonly used ocular hypotensive medication, brimonidine for six weeks.

Conditions

  • Intraocular Pressure

Interventions

DRUG

Brimonidine

One drop of brimonidine in each eye three times a day for six weeks.

DRUG

Artificial tears

Lubricating drops added three times a day for six weeks

Sponsors & Collaborators

  • University of Nebraska

    lead OTHER

Principal Investigators

  • Carol B Toris, PhD · Research Instructor

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-08-01
Primary Completion
2011-10-01
Completion
2011-10-01
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01144494 on ClinicalTrials.gov