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Vaginal, Oral and Systemic Inflammation in Preterm Birth

NCT01142752 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 71

Last updated 2016-08-03

No results posted yet for this study

Summary

The prevalence of preterm birth is not decreasing in the last decades despite of improving health care. Intrauterine infections are important in the etiology of preterm birth but the interconnection of systemic inflammation and preterm birth is not clear. Mechanisms of preterm birth should be assessed as preterm birth is the major risk factor for morbidity and mortality during birth, thus being important for the individual and regarding health costs.

No interventions will be carried out in this study.

Hypotheses:

1. There is a common etiology between oral and vaginal inflammation
2. Bacterial species are similar in vagina and oral cavity
3. There are similar oral and systemic immune reactions which provoke preterm birth
4. Inflammatory markers are found in pregnant women at risk and get back to normal post partum In this matched case control study of pregnant women local, systemic and oral inflammation markers and bacterial load are assessed to find out interconnections between these body compartments to allow for explanation of the etiology of preterm birth.

Conditions

  • Local or Systemic Signs for Infection, Preterm Birth

Sponsors & Collaborators

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Daniel V Surbek, Prof. · University women's hospital Bern

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-11-30
Primary Completion
2015-04-30
Completion
2015-05-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01142752 on ClinicalTrials.gov