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Cytokines in Papillon-Lefèvre Syndrome

NCT01116934 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 17

Last updated 2016-03-24

Study results available
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Summary

Papillon-Lefèvre syndrome (PLS) is characterised by aggressively progressive periodontitis combined with palmo-plantar hyperkeratosis. It is caused by "loss of function" mutations in the cathepsin C gene. The hypothesis behind this study is that PLS patients' PMNs produce more proinflammatory cytokines to compensate for their reduced capacity to neutralize leukotoxin and to eliminate Aggregatibacter actinomycetemcomitans. Production of more interleukin (IL)-8 would result in the attraction of more PMNs. Thus, the aim of this study was to evaluate the cytokine profile in PLS patients' blood cultures.

Conditions

  • Papillon-Lefevre Disease

Sponsors & Collaborators

  • Goethe University

    lead OTHER

Principal Investigators

  • Peter Eickholz, Prof. Dr. · JWG-University

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-07-31
Primary Completion
2007-01-31
Completion
2009-12-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01116934 on ClinicalTrials.gov