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Osteonecrosis in Children With Acute Lymphoblastic Leukemia

NCT01104324 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2010-04-15

No results posted yet for this study

Summary

Acute lymphoblastic leukemia is the most common form of childhood cancer with current treatment survival rates approaching 80%. Improved outcomes show an increased number of survivors at risk for long-term treatment related side effects including osteonecrosis. Osteonecrosis, or bone death, is caused by blood supply loss to the bone causing pain and poor quality of life. The hips, shoulders, knees and ankles may be affected. Pain is the usual presenting symptom and may become severe requiring surgical decompression or replacement of the affected joint. Long-term effects including arthritis and progressive joint difficulties will not be known for decades. This study aims to determine the risk factors for developing osteonecrosis that will lead to information for earlier detection and prevention. The study will be the basis for future intervention and prevention trials.

Conditions

Sponsors & Collaborators

  • C17 Council

    collaborator OTHER

  • Halton, Jacqueline, M.D.

    lead OTHER

Principal Investigators

  • Jacqueline Halton · Childrens Hospital of Easten Ontario

Eligibility

Min Age
5 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-07-31
Primary Completion
2012-12-31
Completion
2012-12-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01104324 on ClinicalTrials.gov