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Hyperbaric Oxygen Therapy for Comatose Patients With Acute Carbon Monoxide Poisoning

NCT01099995 · Status: TERMINATED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 170

Last updated 2010-04-08

No results posted yet for this study

Summary

Carbon monoxide poisoning still places a burden on the healthcare system worldwide. While oxygen therapy is the cornerstone treatment, the role and practical modalities of hyperbaric oxygen therapy (HBO) remain controversial. This study aimed at comparing two sessions of HBO at 2 absolute atmosphere and one session of HBO at 2 absolute atmosphere followed by 4 hours of normobaric oxygen therapy in comatose adult victims of acute domestic carbon monoxide poisoning.

Conditions

  • Carbon Monoxide Poisoning

Interventions

OTHER

Hyperbaric oxygen therapy

one dive at 2 absolute atmosphere (1-hour plateau) with 30 min time for compression and decompression - oxygen was delivered via a full face mask at high concentration to achieve a 100% inspired fraction of oxygen or via mechanical ventilation

OTHER

hyperbaric oxygen therapy

two dives at 2 absolute atmosphere (1-hour plateau) with 30 min of compression and 30 min of decompression - oxygen being delivered via a full face mask at 100% inspired oxygen fraction or via mechanical ventilation

Sponsors & Collaborators

  • Assistance Publique - Hôpitaux de Paris

    collaborator OTHER

  • University of Versailles

    lead OTHER

Principal Investigators

  • Djillali Annane, MD · Assistance Publique - Hôpitaux de Paris

  • Jean Claude Raphael · Assistance Publique - Hôpitaux de Paris

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
15 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1989-10-31
Primary Completion
2000-01-31
Completion
2000-02-29

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01099995 on ClinicalTrials.gov