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HIV Fat Redistribution and the Evaluation of Brown Fat

NCT01098045 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 27

Last updated 2021-08-16

No results posted yet for this study

Summary

The specific aims of this study are to determine whether HIV-infected patients with significant fat redistribution and ectopic fat accumulation have increased brown adipose tissue using 18F-FDG Positron Emission Tomography techniques.

Recent studies suggest down regulation of Dicer, a major component of miRNA has an important role in the differentiation and function of brown and white adipose tissue and may contribute to lipodystrophy. Therefore we will expand on recent research in this area by recruiting HIV-infected men with lipodystrophy. We will perform subcutaneous fat biopsies of the dorsocervical and abdominal fat in a subset of HIV-infected and non-HIV-infected men in order to explore further the question of down regulation of Dicer and its implication on metabolic abnormalities in this population.

Conditions

  • HIV Infections

Sponsors & Collaborators

Principal Investigators

  • Steven Grinspoon, MD · Massachusetts General Hospital

  • Martin Torriani, MD · Massachusetts General Hopsital

Eligibility

Min Age
20 Years
Max Age
60 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-03-31
Primary Completion
2014-06-30
Completion
2015-08-31

Countries

  • United States

Study Locations

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Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01098045 on ClinicalTrials.gov