Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy

Summary

The study aims to observe the short term effect (3-month) of sleep disordered breathing (SDB) on cardiovascular parameters, heart rate variability, endothelial function and surrogate markers of atherosclerosis after acute cerebrovascular events (ACE). The long-term effect (6-24-month) of Continuous Positive Airway Pressure (CPAP) on clinical vascular outcome, cardiovascular parameters, evolution of surrogate of atherosclerosis heart rate variability and endothelial function after ACE is observed over 24 months. A preventive effect of CPAP therapy on cerebro-vascular events in patients with moderate-severe obstructive SDB without sleepiness after ictus or transient ischaemic attack will be evaluated.

Conditions

• TIA
• Ischemic Stroke

Interventions

OTHER

CPAP

Sponsors & Collaborators

• Swiss National Science Foundation

  collaborator OTHER

• Schweizerische Herzstiftung

  collaborator OTHER

• ResMed

  collaborator INDUSTRY

• Philips Respironics

  collaborator INDUSTRY

• Prof. Claudio Bassetti

  lead OTHER_GOV

Principal Investigators

• Claudio Bassetti, Professor · Universitätsspital Bern (Inselspital) und Universität Bern

• Carlo Cereda, Capo CLinica · Neurocentre of Southern Switzerland, Ospedale Civico

• Sebastian Ott, MD · Pneumology, University Hospital, Bern

• Lino Nobili, Prof. MD · Neurology, Stroke Unit, Ospedale Niguarda, Milan, Italy

• Mauro Manconi, MD · Neurocentre of Southern Switzerland, Ospedale Civico

• Peter Young, Prof. MD · Universitätsklinik Münster, Zentrum für Schlafmedizin

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

35 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-07-31

Primary Completion

2016-04-30

Completion

2016-04-30

Countries

• Germany
• Italy
• Switzerland

Study Locations