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Human Kidney Histopathology in Obstructive Jaundice

NCT01090193 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2010-03-19

No results posted yet for this study

Summary

Introduction: Cholemia and bacterial translocation with portal endotoxemia are integral in the pathogenesis of obstructive jaundice (OJ). There is sufficient experimental data about hemodynamic and histopathologic consequences of OJ. On the contrary, pathologic information of renal changes in patients with OJ is still lacking. Therefore; the primary objective of this prospective study is to demonstrate the specific histopathologic changes in kidneys of patients with short-term biliary tract obstruction receiving a standard perioperative medical treatment protocol.

Conditions

  • Patients With Obstructive Jaundice

Interventions

PROCEDURE

Whipple operation,Hepaticojejunostomy

Whipple operation, Hepaticojejunostomy

Sponsors & Collaborators

  • Turkish Ministry of Health Izmir Teaching Hospital

    lead OTHER_GOV

Principal Investigators

  • Adam Uslu, Assoc. Prof. · Izmir Teaching Hospital

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
26 Years
Max Age
86 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-01-31
Primary Completion
2010-03-31
Completion
2010-03-31

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01090193 on ClinicalTrials.gov