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The Effects of C-type Natriuretic Peptide on Human Forearm Blood Vessels

NCT01075776 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2020-05-05

No results posted yet for this study

Summary

To determine the effects of whether increasing CNP concentrations slightly above normal will improve the functioning of blood vessels after the interruption in the flow of blood. In this study we are looking at the function of the blood vessels of the forearm, as a substitute for those in the heart

Conditions

  • Ischaemia-reperfusion (IR) Injury

Interventions

DRUG

C-type natriuretic peptide (CNP)

360 pmol/min for 15 minutes intra-arterially

DRUG

Saline

Sodium Chloride 0.9% intra-arterially 0.5ml/min

DRUG

Acetylcholine

2 stepped infusions for a total 9min per limb, totalling 1.05micromoles per limb

Sponsors & Collaborators

  • University College, London

    collaborator OTHER

  • Queen Mary University of London

    lead OTHER

Principal Investigators

  • Ahluwalia Amrita, BSc PhD · Queen Mary University London

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-01-31
Primary Completion
2022-01-31
Completion
2023-01-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01075776 on ClinicalTrials.gov