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Prevention of Contrast-Induced Nephropathy

NCT00175227 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2011-05-10

No results posted yet for this study

Summary

Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram.

The investigators hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls.

Conditions

  • Contrast-induced Nephropathy
  • Acute Renal Failure
  • Chronic Renal Failure

Interventions

DRUG

intravenous saline hydration + mannitol + furosemide

500 mls half-normal saline + 25g mannitol + 100 mg furosemide

DRUG

intravenous saline hydration

500 mls half-normal saline

Sponsors & Collaborators

  • Alberta Heritage Foundation for Medical Research

    collaborator OTHER

  • University of Alberta

    lead OTHER

Principal Investigators

  • Sumit R Majumdar, MD, MPH · University of Alberta

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1996-05-31
Primary Completion
2000-10-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00175227 on ClinicalTrials.gov