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Post Operative Sore Throat and Dexamethasone

NCT01052038 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2012-05-02

Study results available
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Summary

Sore throat is a common postoperative complaint that can lead to morbidity and patient dissatisfaction . The incidence of sore throat has been reported to be between 6% and 90% even under optimal intubating conditions. There are several factors that have been shown to contribute to postoperative sore throat such as patient related factors, type of anesthesia and type of surgery.

Corticosteroids are also commonly used in the perioperative period to potentiate analgesics and as antiemetics. The preoperative administration of dexamethasone can decrease the incidence and severity of postoperative sore throat which is rated by patients as one of the most undesirable outcomes in the postoperative period.

Conditions

Interventions

DRUG

Placebo administration

Placebo administration

DRUG

Dexamethasone 0.05mg/kr administration

Dexamethasone 0.05mg/kr administered in 100ml of sterile saline solution prior to the start of surgery.

DRUG

Dexamethasone 0.1mg/kg

Dexamethasone 0.1mg/kg administered in 100ml of sterile saline solution prior to the beginning of surgery.

Sponsors & Collaborators

Principal Investigators

  • Gildasio DeOliveira, M.D. · Northwestern University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
64 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-01-31
Primary Completion
2010-09-30
Completion
2010-09-30

Countries

  • United States

Study Locations

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Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01052038 on ClinicalTrials.gov