Valproic Acid in Treating Patients With Previously Treated Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Chronic Lymphocytic Leukemia
NCT01016990 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 52
Last updated 2014-01-10
Summary
RATIONALE: Valproic acid may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. It may also help cancer cells become more like normal cells, and grow and spread more slowly.
PURPOSE: This phase II trial is studying how well valproic acid works in treating patients with previously treated non-Hodgkin Lymphoma, Hodgkin lymphoma, or chronic lymphocytic leukemia.
Conditions
Interventions
- DRUG
-
valproic acid
- GENETIC
-
western blotting
- OTHER
-
laboratory biomarker analysis
- OTHER
-
pharmacological study
Sponsors & Collaborators
-
Auxilio Mutuo Cancer Center
lead OTHER
Principal Investigators
-
Fernando Cabanillas, MD · Auxilio Mutuo Cancer Center
Study Design
- Purpose
- TREATMENT
- Masking
- NONE
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2009-08-31
- Primary Completion
- 2011-09-30
Countries
- Puerto Rico
Study Locations
More Related Trials
-
Biological Therapy After Chemotherapy in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
NCT00012207 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma
NCT01258998 ·Status: COMPLETED ·Phase: PHASE2
-
Study to Assess the Safety, Tolerability and Pharmacokinetics of Fimepinostat (CUDC-907) in Patients With Lymphoma
NCT01742988 ·Status: COMPLETED ·Phase: PHASE1
-
Carfilzomib and Hyper-CVAD in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoma
NCT02293109 ·Status: COMPLETED ·Phase: PHASE1
-
Vorinostat in Treating Patients With Metastatic or Unresectable Solid Tumors or Lymphoma and Liver Dysfunction
NCT00499811 ·Status: COMPLETED ·Phase: PHASE1
-
VEGF Trap in Treating Patients With Solid Tumors or Non-Hodgkin's Lymphoma
NCT00045266 ·Status: COMPLETED ·Phase: PHASE1
-
Adding Targeted Drugs to Usual Chemotherapy for Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LBL)
NCT06210750 ·Status: WITHDRAWN ·Phase: PHASE2
-
VEGF Trap in Treating Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin's Lymphoma
NCT00036946 ·Status: COMPLETED ·Phase: PHASE1
-
huJCAR014 CAR-T Cells in Treating Adult Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia
NCT03103971 ·Status: TERMINATED ·Phase: PHASE1
-
Study of 5-azacitidine in Combination With Vorinostat in Patients With Relapsed or Refractory Diffuse Large b Cell Lymphoma (DLBCL)
NCT01120834 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia
NCT00005977 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy in Treating Patients With Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma
NCT00053105 ·Status: UNKNOWN ·Phase: PHASE1
-
Vorinostat and Lenalidomide in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma
NCT01116154 ·Status: TERMINATED ·Phase: PHASE1
-
Combination Chemotherapy & Lenalidomide in Newly Diagnosed Stage II-IV Peripheral T-cell Non-Hodgkin's Lymphoma
NCT02561273 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma
NCT00003388 ·Status: COMPLETED ·Phase: PHASE2
-
CPI-613 and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma
NCT02168140 ·Status: COMPLETED ·Phase: PHASE1
-
Cellular Immunotherapy Following Chemotherapy in Treating Patients With Recurrent Non-Hodgkin Lymphomas, Chronic Lymphocytic Leukemia, or B-Cell Prolymphocytic Leukemia
NCT02153580 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Trial of Vorinostat in Combination With Cyclophosphamide, Etoposide, Prednisone and Rituximab for Elderly Patients With Relapsed Diffuse Large B-Cell Lymphoma (DLBCL)
NCT00667615 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Cilengitide (EMD 121974) in Treating Patients With Advanced Solid Tumors or Lymphoma
NCT00077155 ·Status: COMPLETED ·Phase: PHASE1
-
Pentostatin, Cyclophosphamide, and Rituximab Followed By Campath-1H in Patients With Relapsed or Refractory B-Cell CLL
NCT00074282 ·Status: COMPLETED ·Phase: PHASE2
-
Bortezomib and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
NCT01769209 ·Status: COMPLETED ·Phase: PHASE2
-
Vorinostat and Rituximab in Treating Patients With Indolent Non-Hodgkin Lymphoma
NCT00720876 ·Status: COMPLETED ·Phase: PHASE2
-
Study of RAD001 in Patients With Relapsed/Refractory Hodgkin Lymphoma That Has Progressed After High-dose Chemotherapy and Autologous Stem Cell Transplant and/or After Gemcitabine- or Vinorelbine- or Vinblastine-based Treatment.
NCT01022996 ·Status: COMPLETED ·Phase: PHASE2
-
CCI-779 in Treating Patients With Recurrent or Refractory B-Cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia
NCT00290472 ·Status: COMPLETED ·Phase: PHASE2
-
Bryostatin 1 in Treating Patients With Relapsed Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia
NCT00002908 ·Status: COMPLETED ·Phase: PHASE2