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Do Changes in Plasma Osmolality Influence Ventilation?

NCT01008644 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2012-10-17

No results posted yet for this study

Summary

Primary hypothesis: osmolality changes influence the sensitivity of the respiratory center to carbon dioxide, hyponatraemia causing hyperventilation, and hypernatraemia depressing ventilation.

Secondary hypothesis: There are gender differences in the sensitivity to osmolality changes.

10 women and 10 men will on different occasions drink water or receive hypertonic saline intravenously, in order to lower or increase plasma osmolality. The women will participate during both faces of the menstruation cycle. On each occasion the subject´s sensitivity to carbon dioxide will be tested, and blood samples will be drawn for analysis of blood gases,electrolyte and osmolality.Subjects who interrupt participation before completion of all planned occasions, will be substituted, so that 10 subjects of either sex will have participated as planned. All results from all participants will be analyzed.

Conditions

  • Hyponatraemia
  • Hypernatraemia

Interventions

OTHER

Water

The subjects will drink tap water for 2 hours, volume calculated according to weight: 20ml/kg/hour.

OTHER

Saline 3%

The subjects will receive saline 3% intravenously for 2 hours, the volume calculated as 0.1 ml/kg/min

Sponsors & Collaborators

  • Vibeke Moen

    lead OTHER

Principal Investigators

  • Lars Irestedt. MD PhD · Department of Anaesthesia and Intensive Care , Karolinska University Hospital, Stockholm

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-11-30
Primary Completion
2010-11-30
Completion
2010-11-30

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01008644 on ClinicalTrials.gov