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Improved Diagnosis of Alzheimer's Disease Using Magnetoencephalography (MEG)

NCT00973518 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 160

Last updated 2010-08-13

No results posted yet for this study

Summary

The current study is intended to enrich and extend the database of Alzheimer's Disease (AD) and healthy control (HC) MEG scans and will include patients meeting DSM-IV-TR criteria for dementia of Alzheimer's type, and age- and gender-matched HC subjects meeting criteria of normal neurological function. This study will include 2 MEG and electroencephalography (EEG) scans on approximately 80 AD subjects and 80 HC subjects over approximately 30 days. All subjects will have MEG/EEG scans at baseline and 28 - 35 days after baseline. Within one day of each scan visit AD subjects will undergo 4 standard functional tests while HC subjects will undergo 2 standard functional tests.

This study will test the following hypotheses:

* MEG scans of resting-state, eyes-open brain function reveal patterns of correlated activity that differ between HC subjects and subjects diagnosed with dementia of Alzheimer's type;
* Patterns of correlated activity measured in AD subjects correspond to other measures of disease severity such as standard functional test scores;
* MEG scan patterns for HC subjects are consistent across repeated measures taken over a 30 day period.

Conditions

Sponsors & Collaborators

  • Orasi Medical, Inc.

    lead INDUSTRY

Principal Investigators

  • Concetta Forchetti, MD, PhD · Alexian Brothers Neuroscience Institute

  • Raj C Shah, MD · Rush Alzheimer's Disease Center

Eligibility

Min Age
50 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-09-30
Primary Completion
2010-06-30
Completion
2010-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00973518 on ClinicalTrials.gov