Dose-Escalation Study in Advanced Colon Cancer Patients
NCT00969046 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2020-12-08
Summary
This study is exploring different administration schedules (short versus prolonged infusion) to optimize the safety and efficacy profile of EPO906A (patupilone) in patients with pretreated advanced colon cancer.
Conditions
Interventions
- DRUG
-
EPO906 (patupilone)
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Novartis Pharmaceuticals · Royal London Hospital
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2003-11-30
- Primary Completion
- 2006-11-30
- Completion
- 2006-11-30
Countries
- Czechia
- France
- Spain
- United Kingdom
Study Locations
More Related Trials
-
Trial of Neoadjuvant Chemotherapy in Locally Advanced Colon Cancer
NCT01675999 ·Status: UNKNOWN ·Phase: PHASE2
-
Clinical Trial of PM60184 in Advanced Colorectal Cancer After Standard Treatment
NCT03427268 ·Status: COMPLETED ·Phase: PHASE2
-
Phase I Study of PN401, Fluorouracil, Leucovorin and CPT-11 in Patients With Solid Tumors
NCT00044785 ·Status: TERMINATED ·Phase: PHASE1
-
Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
NCT00006115 ·Status: UNKNOWN ·Phase: PHASE2
-
Vorinostat, Fluorouracil, and Leucovorin Calcium in Treating Patients With Metastatic Colorectal Cancer That Has Not Responded to Previous Treatment
NCT00942266 ·Status: COMPLETED ·Phase: PHASE2
-
Fluorouracil Plus Leucovorin With or Without Oxaliplatin in Treating Patients With Stage II or Stage III Colon Cancer
NCT00004931 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Previously Treated Metastatic Colorectal Cancer
NCT00056446 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase 1a/b Dose Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of OMP-131R10
NCT02482441 ·Status: COMPLETED ·Phase: PHASE1
-
Fluorouracil and Leucovorin With or Without Oxaliplatin in Treating Patients With Recurrent Metastatic Colorectal Cancer
NCT00016198 ·Status: COMPLETED ·Phase: PHASE2
-
A Trial of an Investigational Drug for the Prevention of Diarrhea Associated With Irinotecan/5FU/Leucovorin Chemotherapy in Previously Untreated Metastatic Colorectal Cancer
NCT00040391 ·Status: TERMINATED ·Phase: PHASE2
-
Comparing Two Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer
NCT00006468 ·Status: UNKNOWN ·Phase: PHASE3
-
A Study of Xeloda (Capecitabine) in Patients With Metastatic Colorectal Cancer
NCT00069108 ·Status: COMPLETED ·Phase: PHASE3
-
Encorafenib + Cetuximab Beyond Progression in Combination With FOLFIRI in Patients With BRAF V600E Mutated Metastatic Colorectal Cancer Progressing on Encorafenib + Cetuximab.
NCT06640166 ·Status: RECRUITING ·Phase: PHASE2
-
Chemotherapy For Metastatic Grade 3 Poorly Differentiated NEuroendocrine Carcinoma Of GastroEnteroPancreatic And Unknown Primary
NCT04325425 ·Status: RECRUITING ·Phase: PHASE2
-
Oxaliplatin ± Nivolumab in Combination With Trifluridine/Tipiracil or 5-fluorouracile in Frail Patients With Advanced, Recurrent or Metastatic Gastric, Oesophageal or Gastroesophageal Junction Cancer
NCT05476796 ·Status: RECRUITING ·Phase: PHASE2
-
A Study of 5 Fluorouracil and the Anti-Tumor Activity of ADH300004 and 5 Fluorouracil in Subjects With Incurable Solid Tumors
NCT00264472 ·Status: SUSPENDED ·Phase: PHASE1
-
Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
NCT00003594 ·Status: COMPLETED ·Phase: PHASE3
-
Vorinostat and IV Fluorouracil/Leucovorin (5FU/LV) in Patients With Metastatic Colorectal Cancer
NCT00336141 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
NCT00004102 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Compare the Efficacy of Arfolitixorin Versus Leucovorin in Combination With 5 Fluorouracil, Oxaliplatin, and Bevacizumab in Patients With Advanced Colorectal Cancer
NCT03750786 ·Status: COMPLETED ·Phase: PHASE3
-
Study Evaluating EKB-569 in Advanced Colorectal Cancer
NCT00072748 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Xeloda (Capecitabine) Plus Oxaliplatin in Patients With Colon Cancer
NCT00069121 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy in Treating Patients With Advanced Cancer
NCT00003956 ·Status: COMPLETED ·Phase: PHASE1
-
Comparison of Three Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer
NCT00008281 ·Status: UNKNOWN ·Phase: PHASE3
-
High-Dose Fluorouracil With or Without Leucovorin Compared With Standard Fluorouracil Plus Leucovorin Following Surgery in Treating Patients With Stage III Colon Cancer
NCT00004150 ·Status: COMPLETED ·Phase: PHASE3