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Lipids Profile in Subclinical Hypothyroidism

NCT00962221 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2016-09-08

No results posted yet for this study

Summary

Overt hypothyroidism is associated with increased risk for cardiovascular disease (CVD) as indicated by hypertension, hypercholesterolemia, and increased low-density lipoprotein cholesterol (LDL-C) levels. Mild hypothyroidism, also called subclinical hypothyroidism \[SH\] is highly prevalent in elderly subjects, especially in women older than 50 years of age. Whether SH is related as a risk for premature CVD is controversial. It was shown that SH is associated with elevated lipids levels, particularly LDL-cholesterol. However recent evidence suggests that the 'quality' rather than only the 'quantity' of LDL-cholesterol exerts a direct influence on the cardiovascular risk. LDL-cholesterol comprises multiple distinct subclasses that differ in their atherogenic potential. Thus, the proposed study protocol is intended to evaluate the different LDL lipoproteins subclasses in patients with subclinical hypothyroidism.

Conditions

  • Subclinical Hypothyroidism

Interventions

PROCEDURE

laboratory analysis

laboratory analysis

Sponsors & Collaborators

  • University of Palermo

    collaborator OTHER

  • University of Zurich

    collaborator OTHER

  • HaEmek Medical Center, Israel

    lead OTHER

Principal Investigators

  • Rafael Luboshitzky, MD · Endocrine Institute, Haemek Medical Center, Afula, Israel

  • Manfredi Rizzo, MD · University of Palermo

  • Giatgen Spinas, MD · University of Zurich

  • Kaspar Berneis, MD · University of Zurich

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-10-31
Primary Completion
2011-10-31
Completion
2012-10-31

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00962221 on ClinicalTrials.gov