Triapine, Cisplatin, and Radiation Therapy in Treating Patients With Cervical Cancer or Vaginal Cancer

Summary

This phase II trial is studying how triapine and cisplatin given together with radiation therapy works in treating patients with cervical cancer or vaginal cancer. Triapine may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving triapine together with cisplatin may make tumor cells more sensitive to radiation therapy.

Conditions

• Recurrent Cervical Cancer
• Recurrent Vaginal Cancer
• Stage IB Cervical Cancer
• Stage II Vaginal Cancer
• Stage IIA Cervical Cancer
• Stage IIB Cervical Cancer
• Stage III Cervical Cancer
• Stage III Vaginal Cancer
• Stage IVA Cervical Cancer
• Stage IVA Vaginal Cancer
• Stage IVB Cervical Cancer
• Stage IVB Vaginal Cancer
• Therapy-related Toxicity

Interventions

DRUG

triapine

Given IV

DRUG

cisplatin

Given IV

RADIATION

external beam radiation therapy

Undergo pelvic external beam radiation therapy

PROCEDURE

quality-of-life assessment

Ancillary studies

OTHER

questionnaire administration

Ancillary studies

RADIATION

fludeoxyglucose F 18

Undergo FDG-PET/CT

PROCEDURE

positron emission tomography

Undergo FDG-PET/CT

PROCEDURE

computed tomography

Undergo FDG-PET/CT

Sponsors & Collaborators

• National Cancer Institute (NCI)

  lead NIH

Principal Investigators

• Charles Kunos · Case Comprehensive Cancer Center

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2009-07-31

Primary Completion

2012-04-30

Completion

2012-07-31

Countries

• United States

Study Locations