MedTrace Logo

Interplay Between Organic Anion Transporting Polypeptide (OATP) Transporters Transporters and CYP2C9 in Glyburide Pharmacokinetics (PK)

NCT00935363 · Status: WITHDRAWN · Phase: PHASE1 · Type: INTERVENTIONAL

Last updated 2015-01-14

No results posted yet for this study

Summary

The purpose of this study is to investigate if the drugs rifampin and fluconazole when given together increase the concentrations in the body of the oral diabetes medication glyburide.

Conditions

  • Healthy

Interventions

DRUG

glyburide

single oral dose

DRUG

glyburide + fluconazole

single dose oral glyburide single dose iv fluconazole

DRUG

glyburide + rifampin

single dose oral glyburide single dose iv rifampin

DRUG

glyburide + fluconazole + rifampin

single dose oral glyburide single dose iv fluconazole single dose iv rifampin

Sponsors & Collaborators

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2010-03-31
Completion
2010-04-30

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00935363 on ClinicalTrials.gov