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Inspiratory Support Improves Preoxygenation in Healthy Subjects

NCT00922753 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2009-06-18

No results posted yet for this study

Summary

Preoxygenation optimizes oxygen content in the functional residual capacity (FRC). Adequate preoxygenation is defined by an expiratory oxygen fraction (FEO2) \> 90%. Inspiratory support and positive end expiratory pressure (PEEP) can create a better reservoir, improve gas exchange and shorten the time needed for adequate preoxygenation. The goal of the study is to evaluate the efficacy and tolerability of different levels of inspiratory support and positive end expiratory pressure during preoxygenation in healthy subjects.

Conditions

  • Healthy

Interventions

OTHER

VS

Spontaneous breathing of 100% oxygen in a facemask for 3 minutes

OTHER

AI-4/PEEP-4

Spontaneous breathing of 100% oxygen in a facemask with application of an inspiratory pressure of 4 cm H2O and a positive end-expiratory pressure of 4 cm H2O, for 3 minutes

OTHER

AI-6/PEEP-4

Spontaneous breathing of 100% oxygen in a facemask with application of an inspiratory pressure of 6 cm H2O and a positive end-expiratory pressure of 4 cm H2O, for 3 minutes.

Sponsors & Collaborators

  • Maisonneuve-Rosemont Hospital

    lead OTHER

Principal Investigators

  • Issam Tanoubi, M.D. · Maisonneuve Rosemont Hospital, University Of Montreal

  • François Donati, PhD, MD, FRCPC · Maisonneuve Rosemont Hospital, University Of Montreal

  • Pierre Drolet, MD, FRCPC · Maisonneuve Rosemont Hospital, University Of Montreal

  • Louis Phillipe Fortier, MSc, MD, FRCPC · Maisonneuve Rosemont Hospital, University Of Montreal

Study Design

Allocation
RANDOMIZED
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-02-28
Primary Completion
2007-09-30
Completion
2007-09-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00922753 on ClinicalTrials.gov