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The Effects of Continuous Positive Airway Pressure on Overlap Syndrome

NCT00914264 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2018-07-18

No results posted yet for this study

Summary

1. The first objective of this study is to determine the differences between, while the airway obstruction severity is the same, and the acute continuous positive airway pressure (CPAP) effect on chronic obstructive pulmonary disease (COPD) patients with overlap syndrome compared with COPD patients without in terms of sleep quality, autonomic nerve activity, biologic markers of systemic inflammatory, and exercise performance.
2. The second objective of this study is to evaluate the subacute (3 months treatment) CPAP effect on COPD patients with overlap syndrome in terms of pulmonary hemodynamic and right heart function, We will also determine the subacute effect of CPAP on sleep and life quality, autonomic nerve activity, biologic markers of systemic inflammatory, as well as exercise performance.
3. The last objective of this study is to evaluate the long term (12 months treatment) CPAP effect on COPD patients with overlap syndrome. The un-scheduled clinic or emergency department visiting, hospitalization, or mortality will be recorded to see if there is significant treatment effect in terms of reducing morbidity and mortality. The long term CPAP effect on sleep and life quality, autonomic nerve activity, biologic markers of systemic inflammatory, exercise performance, as well as pulmonary hemodynamic and right heart function will be re-evaluation.

Conditions

  • COPD & OSA

Interventions

DEVICE

continuous positive airway pressure

CPAP with adequate pressure for 1 day, 3 \& 12 months

Sponsors & Collaborators

  • Chang Gung Memorial Hospital

    lead OTHER

Principal Investigators

  • Yu-Lun Lo, MD · Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan

  • Tsai-Yu Wang, MD · Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan

  • Han-Pin Kuo, MD,PHD · Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-12-31
Primary Completion
2016-11-30
Completion
2016-12-31

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00914264 on ClinicalTrials.gov