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Chromoendoscopy to Decrease the Risk of Colorectal Neoplasia in Lynch Syndrome

NCT00905710 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 240

Last updated 2016-05-13

No results posted yet for this study

Summary

Lynch syndrome (LS), or hereditary nonpolyposis colorectal cancer (HNPCC), is a hereditary disorder predisposing for colorectal cancer. To reduce the risk of colorectal cancer, patients undergo colonoscopy every 1-2 years. Chromoendoscopy is relatively new technique which improves the detection of adenomas, the precursor lesions of colorectal cancer. The aim of this study is to determine whether chromoendoscopy, including polypectomy of all detected lesions, reduces the development of colorectal neoplasia and the need for colectomy in LS patients.

Conditions

Interventions

PROCEDURE

Chromoendoscopy

Chromoendoscopy: spraying of the mucosa of the right colon with indigo-carmine

Sponsors & Collaborators

  • Leiden University Medical Center

    collaborator OTHER

  • Free University Medical Center

    collaborator OTHER

  • University Medical Center Nijmegen

    collaborator OTHER

  • The Netherlands Cancer Institute

    collaborator OTHER

  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

    collaborator OTHER

  • University Medical Center Groningen

    lead OTHER

Principal Investigators

  • Jan J Koornstra, MD PhD · University Medical Center Groningen, netherlands

  • Jan H Kleibeuker, MD PhD · University Medical Center Groningen, Netherlands

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-09-30
Primary Completion
2016-05-31
Completion
2016-05-31

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00905710 on ClinicalTrials.gov