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Analysis of the Clinical and Histological Correlation of Oral Graft-Versus-Host-Disease (GVHD)

NCT00898885 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 41

Last updated 2009-05-12

No results posted yet for this study

Summary

Introduction: Graft-versus-host-disease (GVHD) is the major cause of morbidity and mortality in patients submitted to the Bone Marrow Transplantation (BMT). The oral manifestations can be very debilitating and interfere in the results of medical therapy, leading to systemic complications, committing the prognosis and quality of life of the patient.

The early diagnosis can be done through biopsies of oral mucosa with or without apparent injury clinic. The association between the clinical and histopathological tables of GVHD, especially through the use of recent consensus established in these areas, can bring new benefits to physicians.

Objective: This study aims to apply and compare the two classifications histological to GVHD, Horn (1995) and Consensus (2006) in specimens obtained from clinical oral lesions suggestive of GVHD; correlate them with clinical classification according Akpek (2001) and with the survival of the patients.

Conditions

  • Graft-Versus-Host Disease

Interventions

PROCEDURE

oral biopsy

oral mucosa and salivary gland biopsy after bone marrow transplantation

Sponsors & Collaborators

  • University of Sao Paulo

    lead OTHER

Principal Investigators

  • Marina HG Magalhães, DMD, PhD · University of Sao Paulo - Brazil

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-01-31
Primary Completion
2008-10-31
Completion
2009-04-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00898885 on ClinicalTrials.gov