Impact of Positron Emission Tomography (PET) Imaging in Women With Locally Advanced Cervical Cancer (PET LACE Trial)

Summary

The purpose of this trial is to improve the clinical management and outcome of patients with locally advanced cervical cancer by using positron emission tomography-computed tomography (PET-CT) imaging.

There is considerable debate worldwide regarding the utility of PET for staging cervical cancer. Although there are studies on the accuracy (sensitivity and specificity) of PET in cervical cancer, there are currently no prospective randomized studies on how PET information affects treatment decisions and outcomes.

Conditions

• Cervical Cancer
• Squamous Cell Carcinoma
• Adenosquamous Carcinoma
• Adenocarcinoma

Interventions

PROCEDURE

CT Abdomen and Pelvis scan + whole body PET-CT scan

Pre-treatment scan

PROCEDURE

CT Abdomen and Pelvis scan

Pre-treatment scan

Sponsors & Collaborators

• Ontario Ministry of Health and Long Term Care

  collaborator OTHER_GOV

• Ontario Clinical Oncology Group (OCOG)

  lead OTHER

Principal Investigators

• Laurie Elit, MD · Juravinski Cancer Centre, Canada

• Anthony Fyles, MD · Princess Margaret Hospital, Canada

• Greg Pond, PhD · Ontario Clinical Oncology Group/McMaster University, Department of Oncology

• Mark Levine, MD · Ontario Clinical Oncology Group/McMaster University, Department of Oncology

• Karen Gulenchyn, MD · Hamilton Health Sciences Centre

• Mostafa Atri, MD · University Health Network, Toronto

• Douglas Coyle, PhD · University of Ottawa Epidemiology & Community Medicine

Study Design

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-04-30

Primary Completion

2014-06-30

Completion

2019-08-31

Countries

• Canada

Study Locations