Study of Erlotinib in Combination With Dasatinib
NCT00895128 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 65
Last updated 2015-07-13
Summary
The goal of this clinical research study is to find the highest tolerable dose of Tarceva (erlotinib hydrochloride) that can be given in combination with Sprycel (dasatinib). The safety of this drug combination will also be studied.
Conditions
Interventions
- DRUG
-
Erlotinib Hydrochloride
Starting dose of 100 mg taken by mouth 1 time a day every day for 28 day cycle or 50 mg for pediatric patients.
- DRUG
-
Starting dose of 50 mg by mouth 1 or 2 times a day every day for 28 day cycle.
Sponsors & Collaborators
-
M.D. Anderson Cancer Center
lead OTHER
Principal Investigators
-
Jennifer J. Wheler, MD · M.D. Anderson Cancer Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2009-04-30
- Primary Completion
- 2015-07-31
Countries
- United States
Study Locations
More Related Trials
-
Erlotinib in Combination With Docetaxel in Advanced Hepatocellular and Biliary Tract Carcinomas
NCT00532441 ·Status: TERMINATED ·Phase: PHASE2
-
Different Doses of Dalpicicl Combined With Letrozole in the First-line Treatment of HR-positive, HER2-negative Advanced Breast Cancer
NCT07285382 ·Status: RECRUITING ·Phase: PHASE2
-
Phase II Study of Erlotinib, an EGFR Inhibitor in Metastatic EGFR-positive 'Triple Receptor-negative' Breast Cancer
NCT00739063 ·Status: TERMINATED ·Phase: PHASE2
-
Derazantinib and Atezolizumab in Patients With Urothelial Cancer
NCT04045613 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Vandetanib and Everolimus in Treating Patients With Advanced or Metastatic Cancer
NCT01582191 ·Status: COMPLETED ·Phase: PHASE1
-
A Trial of Erlotinib + Radiotherapy for Cutaneous Squamous Cell Carcinoma
NCT00369512 ·Status: COMPLETED ·Phase: PHASE2
-
ALERT: A Phase II Study of Alternating Eribulin and Hormonal Therapy in Pre-treated ER+ve Breast Cancer.
NCT02681523 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of ERAS-007 as Monotherapy or in Combination With ERAS-601 in Patients With Advanced or Metastatic Solid Tumors
NCT04866134 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Phase I Study of LBH589 & Erlotinib for Advanced Aerodigestive Tract Cancers
NCT00738751 ·Status: COMPLETED ·Phase: PHASE1
-
Treatment of Dalpiciclib Combined With Pyrotinib for Trastuzumab-sensitive HER2+ Advanced Breast Cancer(DAP-Her-02)
NCT05328440 ·Status: RECRUITING ·Phase: PHASE2
-
A Trial of HRS-1358 Tablets in Metastatic or Local Advanced Breast Cancer
NCT05628870 ·Status: RECRUITING ·Phase: PHASE1
-
Atezolizumab, Cobimetinib, and Eribulin in Treating Patients With Chemotherapy Resistant Metastatic Inflammatory Breast Cancer
NCT03202316 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Pyrotinib Combined With Dalpiciclib Combined With Letrozole in ER-positive and HER2-positive Advanced Breast Cancer
NCT07014410 ·Status: RECRUITING ·Phase: PHASE2
-
A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors
NCT06188520 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Multiple Dose Study In Cancer Patients: Safety and Tolerability of BMS-754807 in Combination With Paclitaxel and Carboplatin in Patients With Advanced or Metastatic Solid Tumors
NCT00793897 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer
NCT04288089 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Alpelisib and Enzalutamide in Treating Patients With Androgen Receptor and PTEN Positive Metastatic Breast Cancer
NCT03207529 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Safety and Efficacy of Alpelisib With Everolimus or Alpelisib With Everolimus and Exemestane in Advanced Breast Cancer Patients, Renal Cell Cancer and Pancreatic Tumors
NCT02077933 ·Status: COMPLETED ·Phase: PHASE1
-
Zanzalintinib Combined With Eribulin in Advanced Liposarcoma and Leiomyosarcoma
NCT06957431 ·Status: RECRUITING ·Phase: PHASE1
-
Everolimus and Octreotide in Patients With Advanced Carcinoid Tumor
NCT00412061 ·Status: COMPLETED ·Phase: PHASE3
-
An Exploratory Clinical Study of Dalpiciclib an&Amp;#39;d Letrozole Combined With Anlotinib Neoadjuvant Therapy in Stage II-III Postmenopausal HR+/HER2- Early Breast Cancer
NCT06605690 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
A Comparison Between BMS-690514 and Erlotinib in Patients Who Were Previously Treated for NSCLC
NCT00743938 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of TAS0728 in Patients With Solid Tumors With HER2 or HER3 Abnormalities
NCT03410927 ·Status: TERMINATED ·Phase: PHASE1
-
Pyrotinib Maleate Tablets in Combination With Dalpiciclib Isethionate Tablets and Standard Endocrine Therapy
NCT07189884 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Trial of ZW25 (Zanidatamab) in Patients With Advanced HER2-expressing Cancers
NCT02892123 ·Status: COMPLETED ·Phase: PHASE1