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The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects

NCT00891501 · Status: UNKNOWN · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2009-05-01

No results posted yet for this study

Summary

This study is conducted to assess whether implanting autologous, culture-expanded, mesenchymal stem cells obtained from the bone marrow of patients with early osteoarthritis, cartilage defects or cartilage and underlying bone and cartilage (osteochondral) defects in joints is effective in the treatment of such conditions and alleviation of patients symptoms.

Conditions

  • Degenerative Arthritis
  • Chondral Defects
  • Osteochondral Defects

Interventions

PROCEDURE

Bone Marrow Aspiration

Autologous bone marrow is aspirated from the iliac crest (hip bone) of the patient using a 21-gauge bone marrow aspiration needle under complete aseptic conditions and proper anaesthesia

PROCEDURE

Bone marrow mesenchymal stem cell implantation

The culture expanded mesenchymal stem cell pellet will be implanted into the osteochondral knee defect via open surgery or arthroscopically under complete sterile aseptic conditions and proper anaesthesia. The defect will be covered with an autologous periosteal flap from the proximal tibia and then sealed with human fibrin glue to seal the defect and retain the cell pellet in place

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Principal Investigators

  • Abdel Aziz El Singergy, M.D · Department of Orthopedic Surgery Cairo University School of Medicine

  • Amgad M Haleem, M.Sc(Ortho) · Department of Orthopedic Surgery Cairo University School of Medicne

  • Hazem M Atta, Ph.D · Tissue Culture Unit - Department of Medical Biochemistry - Cairo University School of Medicine

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
15 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-11-30
Primary Completion
2014-12-31
Completion
2014-12-31

Countries

  • Egypt

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00891501 on ClinicalTrials.gov