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Oxidative Stress and Cardiac Arrest

NCT00888966 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2011-07-04

No results posted yet for this study

Summary

Cardiac arrest is a major health problem reaching 375000 cases in Europe each year. Only 5 to 31 % survive after an out of hospital cardiac arrest (OHCA). The main complication after OHCA is the anoxic encephalopathy. Recently mild hypothermia has shown a beneficial effect on survival. But the mechanisms underlying these therapy are not clear.

Cardiac arrest is an example of ischemia reperfusion of the entire body. And it is well demonstrated that reperfusion generates an oxidative stress. But it has never been shown in a clinical setting.

The aim of the study is to evaluate oxidative stress after out of hospital cardiac arrest treated with mild hypothermia.

Conditions

  • Heart Arrest

Sponsors & Collaborators

  • Institut d'Anesthesiologie des Alpes Maritimes

    lead OTHER

Principal Investigators

  • Carole Ichai, MD, PhD · Centre Hospitalier Universitaire de Nice

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-04-30
Primary Completion
2010-06-30
Completion
2010-12-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00888966 on ClinicalTrials.gov