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Efficacy of Caffeine Injection as an Adjuvant to Opioid Therapy in Cancer Pain

NCT00879775 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 41

Last updated 2011-03-29

Study results available
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Summary

Pain is a most common symptom and it has a high impact on quality of life in cancer patients. Many cancer patients have received opioid therapy, but also many of them have suffered from side effects of opioids. Drowsiness and confusion are common side effects of opioids. Caffeine is a well known psychostimulant,and it is widely used as an analgesics. Thus, the investigators aimed to prove the efficacy of intravenous caffeine administration as an adjuvant analgesics to opioids. At the same time, the investigators tried to find that the side effects of opioids could be ameliorated by caffeine.

Conditions

Interventions

DRUG

Caffeine

Intravenous injection of caffeine 200mg with 100ml of normal saline over 1 hour, once a day, for two days.

DRUG

Normal saline

Intravenous injections of 100ml of normal saline over 1 hour, once a day, for two days

Sponsors & Collaborators

  • Korea University Guro Hospital

    collaborator OTHER

  • Korea Research Foundation

    lead OTHER

Principal Investigators

  • Sang-Yeon Suh, M.D.,Ph.D · DongGuk University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-04-30
Primary Completion
2009-07-31
Completion
2009-09-30

Countries

  • South Korea

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00879775 on ClinicalTrials.gov