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Postoperative Pain and SIRS After Preoperative Analgesia With Clonidine or Levobupivacaine

NCT00860899 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2011-11-17

No results posted yet for this study

Summary

The purpose of this study was to investigate hypothesis that preoperative administration of epidural clonidine will reduce postoperative pain and systemic inflammatory stress response better than epidural levobupivacaine.

Conditions

  • Analgesia
  • Pain
  • Systemic Inflammatory Stress Response

Interventions

DRUG

clonidine, levobupivacaine

One hour prior to skin incision, on epidural catheter, patients received 5 µg/kg of clonidine \[Catapres®, Boehringer Ingelheim, Germany\], 7 mL of 0.25% levobupivacaine \[Chirocaine®, Abbott S.p.A., Italy\] or 7 mL of saline.The study was designed to compare clonidine and levobupivacaine, and than both with the control group, in order to asses their analgesic and immunomodulation efficacy.

Sponsors & Collaborators

  • University Hospital Dubrava

    lead OTHER

Principal Investigators

  • Jasminka Persec, MD PhD · Anesthesiology, Resuscitation and Intensive Care Medicine Clinic, University Hospital Dubrava

  • Zoran Persec, MD Msc · Department of Urology, University Hospital Dubrava

  • Ino Husedzinovic, Prof. MD PhD · Anesthesiology, Resuscitation and Intensive Care Medicine Clinic, University Hospital Dubrava

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
42 Years
Max Age
77 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-12-31
Primary Completion
2008-10-31
Completion
2009-05-31

Countries

  • Croatia

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00860899 on ClinicalTrials.gov