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Retinol-induced Dermatitis in Aged Skin

NCT00857610 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 41

Last updated 2020-03-13

No results posted yet for this study

Summary

Topical therapy with retinoids is the only proven medical therapy for aged/photoaged human skin. However, topical therapy with retinoids often result in unwanted cutaneous dermatitis, including erythema and scaling. The reseachers intend to investigate the dose, frequency of use, and time dependence of topical retinol-induced dermatitis. The researchers intend to evaluate retinoid-induced dermatitis biochemically, including retinol regulation of retinoid responsive genes that control retinoid metabolism and serve as markers for retinoid bioactivity. The researchers will also investigate the role of EGF receptor pathway in retinoid-induced dermatitis.

Conditions

  • Aged Skin
  • Photoaged Skin

Sponsors & Collaborators

Principal Investigators

  • Dana Sachs, MD · University of Michigan Professor of Dermatology

Eligibility

Min Age
21 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-07-20
Primary Completion
2014-08-29
Completion
2014-08-29

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00857610 on ClinicalTrials.gov