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The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery

NCT00852410 · Status: UNKNOWN · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 140

Last updated 2010-06-30

No results posted yet for this study

Summary

Obtaining adequate hemostasis is crucial during endoscopic sinus surgery. Submucosal injection of local anaesthetic containing adrenaline has frequently been used to improve surgical milieu. However, injection of adrenaline has potential side effects including tachycardia, hypertension as well as inducing arrhythmia. The aim of this randomized clinical trial is to assess the hemodynamic and hemostatic effects of two different concentrations of adrenaline in local anaesthetic used during endoscopic sinus surgery.

Conditions

  • Chronic Sinusitis

Interventions

DRUG

1% lidocaine with 1:100,000 adrenaline

high dose

DRUG

1% lidocaine with 1:200,000 adrenaline

1% lidocaine with 1:200,000 adrenaline

Sponsors & Collaborators

  • University of Toronto

    lead OTHER

Principal Investigators

  • Ali Moshaver, MD · University of Toronto

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-03-31
Primary Completion
2010-04-30
Completion
2010-04-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00852410 on ClinicalTrials.gov